LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain

LASSBio-1135 is an imidazo[1,2-a]pyridine derivative with high efficacy in screening models of nociception and inflammation, presumed as a weak COX-2 inhibitor. In order to tease out its mechanism of action, we investigated others possible target for LASSBio-1135, such as TNF-α and TRPV1, to better...

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Detalles Bibliográficos
Autores principales: Lima, Cleverton K. F., Silva, Rafael M., Lacerda, Renata B., Santos, Bruna L. R., Silva, Rafaela V., Amaral, Luciana S., Quintas, Luís E. M., Fraga, Carlos A. M., Barreiro, Eliezer J., Guimaraes, Marília Z. P., Miranda, Ana L. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062389/
https://www.ncbi.nlm.nih.gov/pubmed/24941071
http://dx.doi.org/10.1371/journal.pone.0099510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062389/
https://www.ncbi.nlm.nih.gov/pubmed/24941071
http://dx.doi.org/10.1371/journal.pone.0099510

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