Heterogeneous EGFR Gene Copy Number Increase Is Common in Colorectal Cancer and Defines Response to Anti-EGFR Therapy

Anti-EGFR therapy is commonly used to treat colorectal cancer (CRC), although only a subset of patients benefit from the treatment. While KRAS mutation predicts non-responsiveness, positive predictive markers are not in clinical practice. We previously showed that immunohistochemistry (IHC)-guided E...

Descripción completa

Detalles Bibliográficos
Autores principales: Ålgars, Annika, Avoranta, Tuulia, Österlund, Pia, Lintunen, Minnamaija, Sundström, Jari, Jokilehto, Terhi, Ristimäki, Ari, Ristamäki, Raija, Carpén, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062406/
https://www.ncbi.nlm.nih.gov/pubmed/24940619
http://dx.doi.org/10.1371/journal.pone.0099590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062406/
https://www.ncbi.nlm.nih.gov/pubmed/24940619
http://dx.doi.org/10.1371/journal.pone.0099590

Ejemplares similares