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MicroRNA Profiling in Muc2 Knockout Mice of Colitis-Associated Cancer Model Reveals Epigenetic Alterations during Chronic Colitis Malignant Transformation
Our previous studies have demonstrated that genetic deletion of the Muc2 gene causes colorectal cancers in mice. The current study further showed that at the early stage (<3 months) the Muc2 knockout mice spontaneously developed chronic inflammation in colon and rectum, similar pathological featu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062425/ https://www.ncbi.nlm.nih.gov/pubmed/24941171 http://dx.doi.org/10.1371/journal.pone.0099132 |