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CD4(+) T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

CD4(+) T cell differentiation has been shown to be regulated by the cytokine milieu present during activation as well as peptide MHC levels. However, the extent to which these two important regulatory signals work in concert to shape CD4(+) T cell function has not been investigated. Using a murine O...

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Detalles Bibliográficos
Autores principales: Shiner, Erin K., Holbrook, Beth C., Alexander-Miller, Martha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062528/
https://www.ncbi.nlm.nih.gov/pubmed/24940899
http://dx.doi.org/10.1371/journal.pone.0100175