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ADMINISTRATION OF ANTENATAL GLUCOCORTICOIDS AND POSTNATAL SURFACTANT AMELIORATES RESPIRATORY DISTRESS SYNDROME-ASSOCIATED NEONATAL LETHALITY IN ERK3(−/−) PUPS

BACKGROUND: Respiratory distress syndrome (RDS) persists as a prevalent cause of infant morbidity and mortality. We have previously demonstrated that deletion of Erk3 results in pulmonary immaturity and neonatal lethality. Using RNA-Seq, we identified corticotrophin releasing hormone (CRH) and surfa...

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Detalles Bibliográficos
Autores principales: Guaman, Milenka Cuevas, Sbrana, Elena, Shope, Cynthia, Showalter, Lori, Hu, Min, Meloche, Sylvain, Aagaard, Kjersti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062596/
https://www.ncbi.nlm.nih.gov/pubmed/24732107
http://dx.doi.org/10.1038/pr.2014.54