N-Demethylation and N-oxidation of imipramine in rat thoracic aortic endothelial cells

The aim of this study was to examine whether cultured rat thoracic aortic endothelial cells (TAECs) have the ability to metabolize the tertiary amine, imipramine. In rat TAECs, imipramine was biotransformed into N-demethylate and N-oxide by cytochrome P450 (CYP) and flavin-containing monooxygenase (...

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Detalles Bibliográficos
Autores principales: Ueda, Yukari, Yaginuma, Toshihiko, Sakurai, Eiko, Sakurai, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062819/
https://www.ncbi.nlm.nih.gov/pubmed/24647745
http://dx.doi.org/10.1007/s11626-014-9739-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062819/
https://www.ncbi.nlm.nih.gov/pubmed/24647745
http://dx.doi.org/10.1007/s11626-014-9739-0

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