Cargando…

Esters of valerenic acid as potential prodrugs

Valerenic acid (VA) is a β(2/3) subunit-specific modulator of γ-aminobutyric acid (GABA) type A (GABA(A)) receptors inducing anxiolysis. Here we analyze if VA-esters can serve as prodrugs and if different ester structures have different in vitro/in vivo effects. Modulation of GABA(A) receptors expre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hintersteiner, Juliane, Haider, Maximilian, Luger, Denise, Schwarzer, Christoph, Reznicek, Gottfried, Jäger, Walter, Khom, Sophia, Mihovilovic, Marko D., Hering, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2014
Materias:	Behavioural Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062961/ https://www.ncbi.nlm.nih.gov/pubmed/24680924 http://dx.doi.org/10.1016/j.ejphar.2014.03.019

Ejemplares similares

Analysis of β-Subunit-dependent GABA(A) Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives
por: Khom, S., et al.
Publicado: (2016)

Identification of the putative binding pocket of valerenic acid on GABA(A) receptors using docking studies and site‐directed mutagenesis
por: Luger, D, et al.
Publicado: (2015)

Transplacental passage of hyperforin, hypericin, and valerenic acid
por: Spiess, Deborah, et al.
Publicado: (2023)

GABA(A) receptor modulation by piperine and a non-TRPV1 activating derivative()
por: Khom, Sophia, et al.
Publicado: (2013)

Efficient Modulation of γ-Aminobutyric Acid Type A Receptors by Piperine Derivatives
por: Schöffmann, Angela, et al.
Publicado: (2014)

Information transfer efficiency differs in wild chimpanzees and bonobos, but not social cognition
por: Girard-Buttoz, Cédric, et al.
Publicado: (2020)

Perceived efficacy of HIV treatment-as-prevention among university students in Johannesburg, South Africa
por: Bor, Jacob, et al.
Publicado: (2021)

Lifetime reproductive benefits of cooperative polygamy vary for males and females in the acorn woodpecker (Melanerpes formicivorus)
por: Barve, Sahas, et al.
Publicado: (2021)

Structural manipulations of a shelter resource reveal underlying preference functions in a shell-dwelling cichlid fish
por: Bose, Aneesh P. H., et al.
Publicado: (2020)

Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models
por: Hong, Xiaodan, et al.
Publicado: (2022)

The anxiolytic effects of a Valerian extract is based on Valerenic acid
por: Becker, Axel, et al.
Publicado: (2014)

Sex differences in human mate preferences vary across sex ratios
por: Walter, Kathryn V., et al.
Publicado: (2021)

Sexual behaviour and HIV/sexually transmitted infection risk behaviours in the general population of Slovenia, a low HIV prevalence country in central Europe
por: Klavs, I, et al.
Publicado: (2009)

Condom use by female sex workers and their clients in Mexico: who decides and does it matter?
por: Bórquez, Annick, et al.
Publicado: (2011)

HIV-related sexual risk behaviour between 1996 and 2008, according to age, among men who have sex with men (Scotland)
por: Knussen, Christina, et al.
Publicado: (2010)

Circumcision among men who have sex with men in Scotland: limited potential for HIV prevention
por: McDaid, Lisa M, et al.
Publicado: (2010)

Can interfaith research partnerships develop new paradigms for condom use and HIV prevention? The implementation of conceptual events in Malawi results in a ‘spiritualised condom’
por: Willms, Dennis G, et al.
Publicado: (2011)

Intimate partner violence perpetration, standard and gendered STI/HIV risk behaviour, and STI/HIV diagnosis among a clinic-based sample of men
por: Decker, M R, et al.
Publicado: (2009)

Sexually transmitted infection testing and self-reported diagnoses among a community sample of men who have sex with men, in Scotland
por: McDaid, Lisa M, et al.
Publicado: (2013)

Bringing it home: community survey of HIV risks to primary sex partners of men and women in alcohol-serving establishments in Cape Town, South Africa
por: Kalichman, Seth C, et al.
Publicado: (2013)

Vulnerabilities, health needs and predictors of high-risk sexual behaviour among female adolescent sex workers in Kunming, China
por: Zhang, Xu-Dong, et al.
Publicado: (2013)

Alcohol and drug use during unprotected anal intercourse among gay and bisexual men in Scotland: what are the implications for HIV prevention?
por: Li, Jessica, et al.
Publicado: (2014)

Reliance on condoms for contraceptive protection among HIV care and treatment clients: a mixed methods study on contraceptive choice and motivation within a generalised epidemic
por: Church, Kathryn, et al.
Publicado: (2014)

Comprehensive testing for, and diagnosis of, sexually transmissible infections among Australian gay and bisexual men: findings from repeated, cross-sectional behavioural surveillance, 2003–2012
por: Holt, Martin, et al.
Publicado: (2014)

Key factors in the acceptability of treatment as prevention (TasP) in Scotland: a qualitative study with communities affected by HIV
por: Young, I, et al.
Publicado: (2015)

Sexual behaviour among young Danes aged 15–29 years: a cross-sectional study of core indicators
por: Jørgensen, Marianne Johansson, et al.
Publicado: (2015)

Habitual condom use across partner type and sexual position among younger gay and bisexual men: findings from New Zealand HIV behavioural surveillance 2006–2011
por: Lachowsky, N J, et al.
Publicado: (2015)

Dynamics of non-cohabiting sex partnering in sub-Saharan Africa: a modelling study with implications for HIV transmission
por: Omori, Ryosuke, et al.
Publicado: (2015)

The prevalence of, and factors associated with, paying for sex among men resident in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)
por: Jones, Kyle G, et al.
Publicado: (2015)

The SPORTSMART study: a pilot randomised controlled trial of sexually transmitted infection screening interventions targeting men in football club settings
por: Fuller, Sebastian S, et al.
Publicado: (2015)

How long-distance truck drivers and villagers in rural southeastern Tanzania think about heterosexual anal sex: a qualitative study
por: Mtenga, S, et al.
Publicado: (2015)

HIV testing trends among gay men in Scotland, UK (1996–2005): implications for HIV testing policies and prevention
por: Williamson, L M, et al.
Publicado: (2009)

“It pains me because as a woman you have to breastfeed your baby”: decision-making about infant feeding among African women living with HIV in the UK
por: Tariq, Shema, et al.
Publicado: (2016)

Forming new sex partnerships while overseas: findings from the third British National Survey of Sexual Attitudes & Lifestyles (Natsal-3)
por: Tanton, Clare, et al.
Publicado: (2016)

Client-perpetrated and husband-perpetrated violence among female sex workers in Andhra Pradesh, India: HIV/STI risk across personal and work contexts
por: Reed, Elizabeth, et al.
Publicado: (2016)

Finding sexual partners online: prevalence and associations with sexual behaviour, STI diagnoses and other sexual health outcomes in the British population
por: Cabecinha, Melissa, et al.
Publicado: (2017)

First satellite tracks of South Atlantic sea turtle ‘lost years’: seasonal variation in trans-equatorial movement
por: Mansfield, Katherine L., et al.
Publicado: (2017)

Sexual relationships, intimate partner violence and STI partner notification in Cape Town, South Africa: an observational study
por: Mathews, Catherine, et al.
Publicado: (2018)

Maternal modulation of paternal effects on offspring development
por: Mashoodh, Rahia, et al.
Publicado: (2018)

Mortality risk and social network position in resident killer whales: sex differences and the importance of resource abundance
por: Ellis, S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1uvtodqh96s7psi96lkv5pd8f0