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A toggle-switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins
Immature dengue virus particles undergo a dramatic conformational change upon exposure to the acidic environment of the late secretory pathway. The interactions of the E fusion proteins and prM chaperone proteins on the virus envelope are reorganized to permit prM processing by a host protease, furi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063126/ https://www.ncbi.nlm.nih.gov/pubmed/24846574 http://dx.doi.org/10.1038/ncomms4877 |