Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells

A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models. This strategy overcomes many of the limitations of either single agent therapy...

Descripción completa

Detalles Bibliográficos
Autores principales: Beug, Shawn T, LaCasse, Eric C, Korneluk, Robert G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063156/
https://www.ncbi.nlm.nih.gov/pubmed/25050221
http://dx.doi.org/10.4161/onci.28541
_version_ 1782321757412130816
author Beug, Shawn T
LaCasse, Eric C
Korneluk, Robert G
author_facet Beug, Shawn T
LaCasse, Eric C
Korneluk, Robert G
author_sort Beug, Shawn T
collection PubMed
description A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models. This strategy overcomes many of the limitations of either single agent therapy and our results suggest that the combination could be easily and effectively translated to the clinic.
format Online
Article
Text
id pubmed-4063156
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-40631562014-07-21 Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells Beug, Shawn T LaCasse, Eric C Korneluk, Robert G Oncoimmunology Author's View A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models. This strategy overcomes many of the limitations of either single agent therapy and our results suggest that the combination could be easily and effectively translated to the clinic. Landes Bioscience 2014-04-29 /pmc/articles/PMC4063156/ /pubmed/25050221 http://dx.doi.org/10.4161/onci.28541 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Beug, Shawn T
LaCasse, Eric C
Korneluk, Robert G
Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title_full Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title_fullStr Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title_full_unstemmed Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title_short Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
title_sort smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063156/
https://www.ncbi.nlm.nih.gov/pubmed/25050221
http://dx.doi.org/10.4161/onci.28541
work_keys_str_mv AT beugshawnt smacmimeticscombinedwithinnateimmunestimulicreatetheperfectcytokinestormtokilltumorcells
AT lacasseericc smacmimeticscombinedwithinnateimmunestimulicreatetheperfectcytokinestormtokilltumorcells
AT kornelukrobertg smacmimeticscombinedwithinnateimmunestimulicreatetheperfectcytokinestormtokilltumorcells

Ejemplares similares