Pierced Lasso Bundles Are a New Class of Knot-like Motifs

A four-helix bundle is a well-characterized motif often used as a target for designed pharmaceutical therapeutics and nutritional supplements. Recently, we discovered a new structural complexity within this motif created by a disulphide bridge in the long-chain helical bundle cytokine leptin. When o...

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Detalles Bibliográficos
Autores principales: Haglund, Ellinor, Sulkowska, Joanna I., Noel, Jeffrey K., Lammert, Heiko, Onuchic, José N., Jennings, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063663/
https://www.ncbi.nlm.nih.gov/pubmed/24945798
http://dx.doi.org/10.1371/journal.pcbi.1003613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063663/
https://www.ncbi.nlm.nih.gov/pubmed/24945798
http://dx.doi.org/10.1371/journal.pcbi.1003613

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