Disruption of Genes Encoding eIF4E Binding Proteins-1 And -2 Does Not Alter Basal or Sepsis-Induced Changes in Skeletal Muscle Protein Synthesis in Male or Female Mice

Sepsis decreases skeletal muscle protein synthesis in part by impairing mTOR activity and the subsequent phosphorylation of 4E-BP1 and S6K1 thereby controlling translation initiation; however, the relative importance of changes in these two downstream substrates is unknown. The role of 4E-BP1 (and -...

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Detalles Bibliográficos
Autores principales: Steiner, Jennifer L., Pruznak, Anne M., Deiter, Gina, Navaratnarajah, Maithili, Kutzler, Lydia, Kimball, Scot R., Lang, Charles H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063727/
https://www.ncbi.nlm.nih.gov/pubmed/24945486
http://dx.doi.org/10.1371/journal.pone.0099582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063727/
https://www.ncbi.nlm.nih.gov/pubmed/24945486
http://dx.doi.org/10.1371/journal.pone.0099582

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