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Mitochondrial Fusion and ERK Activity Regulate Steroidogenic Acute Regulatory Protein Localization in Mitochondria

The rate-limiting step in the biosynthesis of steroid hormones, known as the transfer of cholesterol from the outer to the inner mitochondrial membrane, is facilitated by StAR, the Steroidogenic Acute Regulatory protein. We have described that mitochondrial ERK1/2 phosphorylates StAR and that mitoch...

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Detalles Bibliográficos
Autores principales: Duarte, Alejandra, Castillo, Ana Fernanda, Podestá, Ernesto J., Poderoso, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063759/
https://www.ncbi.nlm.nih.gov/pubmed/24945345
http://dx.doi.org/10.1371/journal.pone.0100387