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Spontaneous Colitis in Muc2-Deficient Mice Reflects Clinical and Cellular Features of Active Ulcerative Colitis

BACKGROUND: The colonic mucus layer plays a critical role in intestinal homeostasis by limiting contact between luminal bacteria and the mucosal immune system. A defective mucus barrier in animal models allows bacterial contact with the intestinal epithelium and results in spontaneous colitis. A def...

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Detalles Bibliográficos
Autores principales:	Wenzel, Ulf A., Magnusson, Maria K., Rydström, Anna, Jonstrand, Caroline, Hengst, Julia, Johansson, Malin EV., Velcich, Anna, Öhman, Lena, Strid, Hans, Sjövall, Henrik, Hansson, Gunnar C., Wick, Mary Jo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063762/ https://www.ncbi.nlm.nih.gov/pubmed/24945909 http://dx.doi.org/10.1371/journal.pone.0100217

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