Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage. Hypomorphic mutations in Mre11 (which causes an ataxia-telangiectasia-like disease [ATLD]) and mutations...

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Detalles Bibliográficos
Autores principales: Costanzo, Vincenzo, Paull, Tanya, Gottesman, Max, Gautier, Jean
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC406388/
https://www.ncbi.nlm.nih.gov/pubmed/15138496
http://dx.doi.org/10.1371/journal.pbio.0020110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC406388/
https://www.ncbi.nlm.nih.gov/pubmed/15138496
http://dx.doi.org/10.1371/journal.pbio.0020110

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