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Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes
Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage. Hypomorphic mutations in Mre11 (which causes an ataxia-telangiectasia-like disease [ATLD]) and mutations...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC406388/ https://www.ncbi.nlm.nih.gov/pubmed/15138496 http://dx.doi.org/10.1371/journal.pbio.0020110 |