Synthetic Cytotoxicity: Digenic Interactions with TEL1/ATM Mutations Reveal Sensitivity to Low Doses of Camptothecin

Many tumors contain mutations that confer defects in the DNA-damage response and genome stability. DNA-damaging agents are powerful therapeutic tools that can differentially kill cells with an impaired DNA-damage response. The response to DNA damage is complex and composed of a network of coordinate...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xuesong, O’Neil, Nigel J., Moshgabadi, Noushin, Hieter, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063919/
https://www.ncbi.nlm.nih.gov/pubmed/24653001
http://dx.doi.org/10.1534/genetics.114.161307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063919/
https://www.ncbi.nlm.nih.gov/pubmed/24653001
http://dx.doi.org/10.1534/genetics.114.161307

Ejemplares similares