Cargando…

Enhanced Vaccine-Induced CD8(+) T Cell Responses to Malaria Antigen ME-TRAP by Fusion to MHC Class II Invariant Chain

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4(+) T cells, but enhanced CD8(+) T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest. In this study we assessed whether fusion of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spencer, Alexandra J., Cottingham, Matthew G., Jenks, Jennifer A., Longley, Rhea J., Capone, Stefania, Colloca, Stefano, Folgori, Antonella, Cortese, Riccardo, Nicosia, Alfredo, Bregu, Migena, Hill, Adrian V. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063960/ https://www.ncbi.nlm.nih.gov/pubmed/24945248 http://dx.doi.org/10.1371/journal.pone.0100538

Ejemplares similares

Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans
por: Capone, Stefania, et al.
Publicado: (2020)

4-1BBL Enhances CD8(+) T Cell Responses Induced by Vectored Vaccines in Mice but Fails to Improve Immunogenicity in Rhesus Macaques
por: Spencer, Alexandra J., et al.
Publicado: (2014)

Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8(+) T Cell Responses
por: Halbroth, Benedict R., et al.
Publicado: (2018)

Antigen‐specific CD8 T cells in cell cycle circulate in the blood after vaccination
por: Simonetti, Sonia, et al.
Publicado: (2019)

Engineered Viruses as Vaccine Platforms
por: Folgori, Antonella, et al.
Publicado: (2012)

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals
por: Hodgson, Susanne H., et al.
Publicado: (2015)

Safety and Immunogenicity of Heterologous Prime-Boost Immunisation with Plasmodium falciparum Malaria Candidate Vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in Healthy Gambian and Kenyan Adults
por: Ogwang, Caroline, et al.
Publicado: (2013)

Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome
por: Fortin, Jean-Simon, et al.
Publicado: (2013)

Accelerating vaccine development and deployment: report of a Royal Society satellite meeting
por: Bregu, Migena, et al.
Publicado: (2011)

Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments
Publicado: (1996)

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain
Publicado: (1986)

Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection
por: Swadling, Leo, et al.
Publicado: (2016)

Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates
por: Spencer, Alexandra J., et al.
Publicado: (2012)

Development of an In Vitro Assay and Demonstration of Plasmodium berghei Liver-Stage Inhibition by TRAP-Specific CD8(+) T Cells
por: Longley, Rhea J., et al.
Publicado: (2015)

High Levels of MeCP2 Depress MHC Class I Expression in Neuronal Cells
por: Miralvès, Julie, et al.
Publicado: (2007)

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules
Publicado: (1996)

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
por: Wooldridge, Linda, et al.
Publicado: (2007)

Assessment of novel vaccination regimens using viral vectored liver stage malaria vaccines encoding ME-TRAP
por: Bliss, Carly M., et al.
Publicado: (2018)

Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates
por: Pierantoni, Angiolo, et al.
Publicado: (2015)

Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication
por: Xu, Huanbin, et al.
Publicado: (2017)

Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19
por: Agrati, Chiara, et al.
Publicado: (2021)

Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans
por: Kelly, Christabel, et al.
Publicado: (2016)

Modification of Adenovirus vaccine vector-induced immune responses by expression of a signalling molecule
por: Rollier, Christine S., et al.
Publicado: (2020)

MHC class I multimers
por: Sun, Mei-Yi, et al.
Publicado: (2001)

Structural Properties of MHC Class II Ligands, Implications for the Prediction of MHC Class II Epitopes
por: Jørgensen, Kasper Winther, et al.
Publicado: (2010)

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment
Publicado: (1994)

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines
Publicado: (1994)

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1(b) with TAP-Independent Peptides Are Semi-Invariant Lymphocytes
por: Doorduijn, Elien M., et al.
Publicado: (2018)

A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C
por: Napolitano, Federico, et al.
Publicado: (2020)

Correction: A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C
por: Napolitano, Federico, et al.
Publicado: (2021)

Ligation of MHC Class II Induces PKC-Dependent Clathrin-Mediated Endocytosis of MHC Class II
por: Masaki, Kento, et al.
Publicado: (2020)

Adopting the rapamycin trapping assay to track the trafficking of murine MHC class I alleles, H-2K(b)
por: Ghanem, Esther, et al.
Publicado: (2015)

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules
por: Ferrari, Giorgio, et al.
Publicado: (1997)

Identification of 34 Novel Proinflammatory Proteins in a Genome-Wide Macrophage Functional Screen
por: Wyllie, David H., et al.
Publicado: (2012)

Superantigen and class II MHC molecules.
por: Kim, J.
Publicado: (1995)

Organizing MHC Class II Presentation
por: Fooksman, David R.
Publicado: (2014)

MHC Class II Presentation in Autoimmunity
por: Ishina, Irina A., et al.
Publicado: (2023)

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation
por: Wieczorek, Marek, et al.
Publicado: (2017)

Safety and Immunogenicity of ChAd63 and MVA ME-TRAP in West African Children and Infants
por: Afolabi, Muhammed O, et al.
Publicado: (2016)

Cross‐reactivity of hepatitis C virus specific vaccine‐induced T cells at immunodominant epitopes
por: Kelly, Christabel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kb7hl7a694btfb3vk31vapehdv