Barrier to Autointegration Factor Becomes Dephosphorylated during HSV-1 Infection and Can Act as a Host Defense by Impairing Viral DNA Replication and Gene Expression

BAF (Barrier to Autointegration Factor) is a highly conserved DNA binding protein that senses poxviral DNA in the cytoplasm and tightly binds to the viral genome to interfere with DNA replication and transcription. To counteract BAF, a poxviral-encoded protein kinase phosphorylates BAF, which render...

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Detalles Bibliográficos
Autores principales: Jamin, Augusta, Thunuguntla, Prasanth, Wicklund, April, Jones, Clinton, Wiebe, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063967/
https://www.ncbi.nlm.nih.gov/pubmed/24945635
http://dx.doi.org/10.1371/journal.pone.0100511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063967/
https://www.ncbi.nlm.nih.gov/pubmed/24945635
http://dx.doi.org/10.1371/journal.pone.0100511

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