TCF-1 and LEF-1 act upstream of Th-POK to promote CD4(+) T cell lineage choice and cooperate with Runx3 to silence the Cd4 gene in CD8(+) T cells

TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double positive (DP) stage are unknown. By specific ablation in DP thymocytes, we demonstrated that deficiency in TCF-1 and LEF-1 diminished CD4(+) T cell output and redirected CD4(+) T cells to a CD8...

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Detalles Bibliográficos
Autores principales: Steinke, Farrah C., Yu, Shuyang, Zhou, Xinyuan, He, Bing, Yang, Wenjing, Zhou, Bo, Kawamoto, Hiroshi, Zhu, Jun, Tan, Kai, Xue, Hai-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064003/
https://www.ncbi.nlm.nih.gov/pubmed/24836425
http://dx.doi.org/10.1038/ni.2897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064003/
https://www.ncbi.nlm.nih.gov/pubmed/24836425
http://dx.doi.org/10.1038/ni.2897

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