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TCF-1 and LEF-1 act upstream of Th-POK to promote CD4(+) T cell lineage choice and cooperate with Runx3 to silence the Cd4 gene in CD8(+) T cells
TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double positive (DP) stage are unknown. By specific ablation in DP thymocytes, we demonstrated that deficiency in TCF-1 and LEF-1 diminished CD4(+) T cell output and redirected CD4(+) T cells to a CD8...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064003/ https://www.ncbi.nlm.nih.gov/pubmed/24836425 http://dx.doi.org/10.1038/ni.2897 |