Rational design and validation of a Tip60 histone acetyltransferase inhibitor

Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general...

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Detalles Bibliográficos
Autores principales: Gao, Chunxia, Bourke, Emer, Scobie, Martin, Famme, Melina Arcos, Koolmeister, Tobias, Helleday, Thomas, Eriksson, Leif A., Lowndes, Noel F., Brown, James A. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064327/
https://www.ncbi.nlm.nih.gov/pubmed/24947938
http://dx.doi.org/10.1038/srep05372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064327/
https://www.ncbi.nlm.nih.gov/pubmed/24947938
http://dx.doi.org/10.1038/srep05372

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