Design of synthetic yeast promoters via tuning of nucleosome architecture

Model-based design of biological parts is a critical goal of synthetic biology, especially for eukaryotes. Here we demonstrate that nucleosome architecture can play a role in defining yeast promoter activity and utilize a computationally-guided approach that can enable both the redesign of endogenou...

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Detalles Bibliográficos
Autores principales: Curran, Kathleen A., Crook, Nathan C., Karim, Ashty S., Gupta, Akash, Wagman, Allison M., Alper, Hal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064463/
https://www.ncbi.nlm.nih.gov/pubmed/24862902
http://dx.doi.org/10.1038/ncomms5002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064463/
https://www.ncbi.nlm.nih.gov/pubmed/24862902
http://dx.doi.org/10.1038/ncomms5002

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