Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mechanisms remain unclear. We explored roles for astrocytes, which display mutant huntingtin in HD patients and mouse models. We found that symptom onset in R6/2 and Q175 HD mouse mo...

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Detalles Bibliográficos
Autores principales: Tong, Xiaoping, Ao, Yan, Faas, Guido C., Nwaobi, Sinifunanya E., Xu, Ji, Haustein, Martin D., Anderson, Mark A., Mody, Istvan, Olsen, Michelle L., Sofroniew, Michael V., Khakh, Baljit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064471/
https://www.ncbi.nlm.nih.gov/pubmed/24686787
http://dx.doi.org/10.1038/nn.3691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064471/
https://www.ncbi.nlm.nih.gov/pubmed/24686787
http://dx.doi.org/10.1038/nn.3691

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