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Defined α-synuclein prion-like molecular assemblies spreading in cell culture

BACKGROUND: α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy. Several findings from cell culture and mouse experiments suggest intercellular...

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Detalles Bibliográficos
Autores principales: Aulić, Suzana, Le, Tran Thanh Nhat, Moda, Fabio, Abounit, Saïda, Corvaglia, Stefania, Casalis, Loredana, Gustincich, Stefano, Zurzolo, Chiara, Tagliavini, Fabrizio, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064824/
https://www.ncbi.nlm.nih.gov/pubmed/24898419
http://dx.doi.org/10.1186/1471-2202-15-69