Cargando…

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

BACKGROUND: α-Synuclein (α-syn) plays a central role in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson disease, dementia with Lewy bodies and multiple system atrophy. Several findings from cell culture and mouse experiments suggest intercellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aulić, Suzana, Le, Tran Thanh Nhat, Moda, Fabio, Abounit, Saïda, Corvaglia, Stefania, Casalis, Loredana, Gustincich, Stefano, Zurzolo, Chiara, Tagliavini, Fabrizio, Legname, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064824/ https://www.ncbi.nlm.nih.gov/pubmed/24898419 http://dx.doi.org/10.1186/1471-2202-15-69

Ejemplares similares

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication
por: Aulić, Suzana, et al.
Publicado: (2017)

Synthetic prions with novel strain-specified properties
por: Moda, Fabio, et al.
Publicado: (2015)

Serpin Signatures in Prion and Alzheimer’s Diseases
por: Zattoni, Marco, et al.
Publicado: (2022)

Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine
por: Zhu, Seng, et al.
Publicado: (2017)

In vitro aggregation assays for the characterization of α-synuclein prion-like properties
por: Narkiewicz, Joanna, et al.
Publicado: (2014)

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
por: Scialò, Carlo, et al.
Publicado: (2021)

Prion-like spreading of pathological α-synuclein in brain
por: Masuda-Suzukake, Masami, et al.
Publicado: (2013)

Small-Molecule Theranostic Probes: A Promising Future in Neurodegenerative Diseases
por: Aulić, Suzana, et al.
Publicado: (2013)

Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions
por: Corvaglia, Stefania, et al.
Publicado: (2014)

α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice
por: Butler, Yemima R., et al.
Publicado: (2022)

Differential overexpression of SERPINA3 in human prion diseases
por: Vanni, S., et al.
Publicado: (2017)

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia
por: Redaelli, Veronica, et al.
Publicado: (2017)

The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
por: Jan, Asad, et al.
Publicado: (2021)

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
por: Legname, Giuseppe
Publicado: (2023)

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
por: Bistaffa, Edoardo, et al.
Publicado: (2019)

The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases
por: Victoria, Guiliana Soraya, et al.
Publicado: (2017)

Elucidating the function of the prion protein
por: Legname, Giuseppe
Publicado: (2017)

Prion protein and aging
por: Gasperini, Lisa, et al.
Publicado: (2014)

Site-specific analysis of N-glycans from different sheep prion strains
por: Nakić, Natali, et al.
Publicado: (2021)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
por: Dunning, Christopher J.R., et al.
Publicado: (2013)

Correction: Site-specific analysis of N-glycans from different sheep prion strains
por: Nakić, Natali, et al.
Publicado: (2021)

Translational Research in Alzheimer’s and Prion Diseases
por: Di Fede, Giuseppe, et al.
Publicado: (2018)

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene
por: Di Fede, Giuseppe, et al.
Publicado: (2019)

PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
por: Bistaffa, Edoardo, et al.
Publicado: (2021)

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
por: Giachin, Gabriele, et al.
Publicado: (2015)

De novo prions
por: Benetti, Federico, et al.
Publicado: (2010)

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils
por: Veys, Lien, et al.
Publicado: (2021)

Different tau fibril types reduce prion level in chronically and de novo infected cells
por: Celauro, Luigi, et al.
Publicado: (2023)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
por: Scialò, Carlo, et al.
Publicado: (2019)

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?
por: Sacino, Amanda N, et al.
Publicado: (2012)

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
por: De Luca, Chiara Maria Giulia, et al.
Publicado: (2019)

Structural Consequences of Copper Binding to the Prion Protein
por: Salzano, Giulia, et al.
Publicado: (2019)

New insights into structural determinants of prion protein folding and stability
por: Benetti, Federico, et al.
Publicado: (2015)

Contributions of Molecular and Optical Techniques to the Clinical Diagnosis of Alzheimer’s Disease
por: Bistaffa, Edoardo, et al.
Publicado: (2020)

The Prion 2018 round tables (II): Aβ, tau, α-synuclein… are they prions, prion-like proteins, or what?
por: Eraña, Hasier
Publicado: (2019)

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
por: Rösener, Nadine S., et al.
Publicado: (2020)

Prion replication environment defines the fate of prion strain adaptation
por: Katorcha, Elizaveta, et al.
Publicado: (2018)

Prion Protein-Specific Antibodies-Development, Modes of Action and Therapeutics Application
por: Rovis, Tihana Lenac, et al.
Publicado: (2014)

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases
por: Legname, Giuseppe, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_49p16ie310slo7230voi11fc70