Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

GGGGCC repeat expansions of C9orf72 represent the most common genetic variant of amyotrophic lateral sclerosis and frontotemporal degeneration, but the mechanism of pathogenesis is unclear. Recent reports have suggested that the transcribed repeat might form toxic RNA foci that sequester various RNA...

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Detalles Bibliográficos
Autores principales: Cooper-Knock, Johnathan, Walsh, Matthew J., Higginbottom, Adrian, Robin Highley, J., Dickman, Mark J., Edbauer, Dieter, Ince, Paul G., Wharton, Stephen B., Wilson, Stuart A., Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065024/
https://www.ncbi.nlm.nih.gov/pubmed/24866055
http://dx.doi.org/10.1093/brain/awu120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065024/
https://www.ncbi.nlm.nih.gov/pubmed/24866055
http://dx.doi.org/10.1093/brain/awu120

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