Inherited Polymorphisms in Hyaluronan Synthase 1 Predict Risk of Systemic B-Cell Malignancies but Not of Breast Cancer

Genetic variations in the hyaluronan synthase 1 gene (HAS1) influence HAS1 aberrant splicing. HAS1 is aberrantly spliced in malignant cells from multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), but not in their counterparts from healthy donors. The presence of aberrant HAS1 splice varia...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuppusamy, Hemalatha, Ogmundsdottir, Helga M., Baigorri, Eva, Warkentin, Amanda, Steingrimsdottir, Hlif, Haraldsdottir, Vilhelmina, Mant, Michael J., Mackey, John, Johnston, James B., Adamia, Sophia, Belch, Andrew R., Pilarski, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065063/
https://www.ncbi.nlm.nih.gov/pubmed/24950197
http://dx.doi.org/10.1371/journal.pone.0100691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065063/
https://www.ncbi.nlm.nih.gov/pubmed/24950197
http://dx.doi.org/10.1371/journal.pone.0100691

Ejemplares similares