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Extensive Conformational Heterogeneity within Protein Cores

[Image: see text] Basic principles of statistical mechanics require that proteins sample an ensemble of conformations at any nonzero temperature. However, it is still common to treat the crystallographic structure of a protein as the structure of its native state, largely because high-resolution str...

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Detalles Bibliográficos
Autores principales: Bowman, Gregory R., Geissler, Phillip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065209/
https://www.ncbi.nlm.nih.gov/pubmed/24564338
http://dx.doi.org/10.1021/jp4105823