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Extensive Conformational Heterogeneity within Protein Cores
[Image: see text] Basic principles of statistical mechanics require that proteins sample an ensemble of conformations at any nonzero temperature. However, it is still common to treat the crystallographic structure of a protein as the structure of its native state, largely because high-resolution str...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065209/ https://www.ncbi.nlm.nih.gov/pubmed/24564338 http://dx.doi.org/10.1021/jp4105823 |