The contribution of dormant origins to genome stability: From cell biology to human genetics

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a stron...

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Detalles Bibliográficos
Autores principales: Alver, Robert C., Chadha, Gaganmeet Singh, Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065331/
https://www.ncbi.nlm.nih.gov/pubmed/24767947
http://dx.doi.org/10.1016/j.dnarep.2014.03.012
Descripción
Sumario:The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.

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