The contribution of dormant origins to genome stability: From cell biology to human genetics

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a stron...

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Detalles Bibliográficos
Autores principales: Alver, Robert C., Chadha, Gaganmeet Singh, Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065331/
https://www.ncbi.nlm.nih.gov/pubmed/24767947
http://dx.doi.org/10.1016/j.dnarep.2014.03.012
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author Alver, Robert C.
Chadha, Gaganmeet Singh
Blow, J. Julian
author_facet Alver, Robert C.
Chadha, Gaganmeet Singh
Blow, J. Julian
author_sort Alver, Robert C.
collection PubMed
description The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins.
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spelling pubmed-40653312014-07-01 The contribution of dormant origins to genome stability: From cell biology to human genetics Alver, Robert C. Chadha, Gaganmeet Singh Blow, J. Julian DNA Repair (Amst) Article The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins. Elsevier 2014-07 /pmc/articles/PMC4065331/ /pubmed/24767947 http://dx.doi.org/10.1016/j.dnarep.2014.03.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Alver, Robert C.
Chadha, Gaganmeet Singh
Blow, J. Julian
The contribution of dormant origins to genome stability: From cell biology to human genetics
title The contribution of dormant origins to genome stability: From cell biology to human genetics
title_full The contribution of dormant origins to genome stability: From cell biology to human genetics
title_fullStr The contribution of dormant origins to genome stability: From cell biology to human genetics
title_full_unstemmed The contribution of dormant origins to genome stability: From cell biology to human genetics
title_short The contribution of dormant origins to genome stability: From cell biology to human genetics
title_sort contribution of dormant origins to genome stability: from cell biology to human genetics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065331/
https://www.ncbi.nlm.nih.gov/pubmed/24767947
http://dx.doi.org/10.1016/j.dnarep.2014.03.012
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