Dual regulation of β(2)-adrenoceptor messenger RNA expression in human lung fibroblasts by β(2)–cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression

Based on their bronchodilatory effect, β(2)-adrenoceptor agonists constitute essential elements in the treatment of bronchial asthma and COPD. As treatment with β(2)-adrenoceptor agonists has been associated with worsening of airway hyper-reactivity, possibly because of loss of β-adrenoceptor functi...

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Detalles Bibliográficos
Autores principales: Kämpfer, N., Lamyel, F., Schütz, I., Warnken, M., Hoffmann, K., von Kügelgen, I., Racké, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065340/
https://www.ncbi.nlm.nih.gov/pubmed/24705868
http://dx.doi.org/10.1007/s00210-014-0971-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065340/
https://www.ncbi.nlm.nih.gov/pubmed/24705868
http://dx.doi.org/10.1007/s00210-014-0971-7

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