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An affective disorder in zebrafish with mutation of the glucocorticoid receptor
Upon binding of cortisol, the glucocorticoid receptor (GR) regulates the transcription of specific target genes, including those that encode the stress hormones corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH). Dysregulation of the stress axis is a hallmark of major depre...
Autores principales: | Ziv, Limor, Muto, Akira, Schoonheim, Peter J., Meijsing, Sebastiaan H., Strasser, Daniel, Ingraham, Holly A., Schaaf, Marcel J.M., Yamamoto, Keith R., Baier, Herwig |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065652/ https://www.ncbi.nlm.nih.gov/pubmed/22641177 http://dx.doi.org/10.1038/mp.2012.64 |
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