Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and In Vivo Studies

The objective of this investigation was to improve the solubility of the poorly water soluble drug atorvastatin (ATR), using solid dispersion (SD) techniques, with Neem Gum (NG) as a hydrophilic carrier. The effects of the polymer concentration and method of preparation on the solubility and dissolu...

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Detalles Bibliográficos
Autores principales: Rodde, Madhuri S., Divase, Ganesh T., Devkar, Tejas B., Tekade, Avinash R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065680/
https://www.ncbi.nlm.nih.gov/pubmed/24995297
http://dx.doi.org/10.1155/2014/463895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065680/
https://www.ncbi.nlm.nih.gov/pubmed/24995297
http://dx.doi.org/10.1155/2014/463895

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