Cargando…

Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and In Vivo Studies

The objective of this investigation was to improve the solubility of the poorly water soluble drug atorvastatin (ATR), using solid dispersion (SD) techniques, with Neem Gum (NG) as a hydrophilic carrier. The effects of the polymer concentration and method of preparation on the solubility and dissolu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodde, Madhuri S., Divase, Ganesh T., Devkar, Tejas B., Tekade, Avinash R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065680/ https://www.ncbi.nlm.nih.gov/pubmed/24995297 http://dx.doi.org/10.1155/2014/463895

Ejemplares similares

Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
por: Bhalani, Dixit V., et al.
Publicado: (2022)

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs
por: Tekade, Avinash Ramrao, et al.
Publicado: (2020)

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate
por: Yousaf, Abid Mehmood, et al.
Publicado: (2016)

Development and Characterization of Pentaerythritol-EudragitRS100 Co-processed Excipients as Solid Dispersion Carriers for Enhanced Aqueous Solubility, In Vitro Dissolution, and Ex Vivo Permeation of Atorvastatin
por: Telange, Darshan R., et al.
Publicado: (2023)

A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies
por: Narayan, Reema, et al.
Publicado: (2017)

Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs
por: Cho, Eunae, et al.
Publicado: (2015)

Nanocrystalization: An Emerging Technology to Enhance the  Bioavailability of Poorly Soluble Drugs
por: Joshi, Kavita, et al.
Publicado: (2019)

Cationic Perylene Antivirals with Aqueous Solubility for Studies In Vivo
por: Shtro, Anna A., et al.
Publicado: (2022)

Ex Vivo Conjunctival Retention and Transconjunctival Transport of Poorly Soluble Drugs Using Polymeric Micelles
por: Pescina, Silvia, et al.
Publicado: (2019)

Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
por: Censi, Roberta, et al.
Publicado: (2015)

Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation
por: Arslan, Aslıhan, et al.
Publicado: (2023)

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability
por: Giri, Bhupendra Raj, et al.
Publicado: (2022)

Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs
por: Nanjwade, Basavaraj K., et al.
Publicado: (2011)

Cocrystal of Apixaban–Quercetin: Improving Solubility and Bioavailability of Drug Combination of Two Poorly Soluble Drugs
por: Zhang, Li, et al.
Publicado: (2021)

Fabrication, in vitro and ex vivo evaluation of proliposomes and liposomal derived gel for enhanced solubility and permeability of diacerein
por: Shah, Hassan, et al.
Publicado: (2021)

Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
por: Lee, Ju-Hyun, et al.
Publicado: (2021)

High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin
por: Kadokawa, Riki, et al.
Publicado: (2021)

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
por: Gigliobianco, Maria Rosa, et al.
Publicado: (2018)

Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide
por: Ali, Mohamed A., et al.
Publicado: (2021)

Central Composite Design Implemented Azilsartan Medoxomil Loaded Nanoemulsion to Improve Its Aqueous Solubility and Intestinal Permeability: In Vitro and Ex Vivo Evaluation
por: Kumar, Girish, et al.
Publicado: (2022)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Zhang, Xingwang, et al.
Publicado: (2018)

Development of self-nanoemulsifying drug delivery systems for the enhancement of solubility and oral bioavailability of fenofibrate, a poorly water-soluble drug
por: Mohsin, Kazi, et al.
Publicado: (2016)

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs
por: Sharma, Mayank, et al.
Publicado: (2016)

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs
por: Kumari, Lakshmi, et al.
Publicado: (2023)

Ex Vivo and in Vivo Study of Sucrosomial(®) Iron Intestinal Absorption and Bioavailability
por: Fabiano, Angela, et al.
Publicado: (2018)

Cyclic Glucans Enhance Solubility of Bioavailable Flavonoids
por: Park, Seyeon
Publicado: (2016)

Solubility and Bioavailability Enhancement of Oridonin: A Review
por: Zhang, Yuanyuan, et al.
Publicado: (2020)

Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
por: Shao, Huili, et al.
Publicado: (2021)

Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods
por: Józsa, Liza, et al.
Publicado: (2023)

Drug Resinates an Attractive Approach of Solubility Enhancement of Atorvastatin Calcium
por: Kulthe, V. V., et al.
Publicado: (2013)

Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique
por: Li, Haiying, et al.
Publicado: (2016)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Enhancing Giardicidal Activity and Aqueous Solubility through the Development of “RetroABZ”, a Regioisomer of Albendazole: In Vitro, In Vivo, and In Silico Studies †
por: Martínez-Conde, Carlos, et al.
Publicado: (2023)

Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges
por: Bhakay, Anagha, et al.
Publicado: (2018)

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Sharma, Arvind, et al.
Publicado: (2022)

Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
por: Jiang, Yihua, et al.
Publicado: (2022)

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
por: Sathisaran, Indumathi, et al.
Publicado: (2018)

Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
por: Liu, Qian, et al.
Publicado: (2022)

Atorvastatin solid dispersion for bioavailability enhancement
por: Shamsuddin,, et al.
Publicado: (2016)

Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
por: Tan, Sui Ling Janet, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ssshlmc1d7m81rvusfv6nqgod