Cargando…

Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site Conformations

The crystal structure of mouse thymidylate synthase (mTS) in complex with substrate dUMP and antifolate inhibitor Raltitrexed is reported. The structure reveals, for the first time in the group of mammalian TS structures, a well-ordered segment of 13 N-terminal amino acids, whose ordered conformatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Dowierciał, Anna, Wilk, Piotr, Rypniewski, Wojciech, Rode, Wojciech, Jarmuła, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065713/
https://www.ncbi.nlm.nih.gov/pubmed/24995339
http://dx.doi.org/10.1155/2014/945803