Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system

Introducing a point mutation is a fundamental method used to demonstrate the roles of particular nucleotides or amino acids in the genetic elements or proteins, and is widely used in in vitro experiments based on cultured cells and exogenously provided DNA. However, the in vivo application of this a...

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Detalles Bibliográficos
Autores principales: Inui, Masafumi, Miyado, Mami, Igarashi, Maki, Tamano, Moe, Kubo, Atsushi, Yamashita, Satoshi, Asahara, Hiroshi, Fukami, Maki, Takada, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066261/
https://www.ncbi.nlm.nih.gov/pubmed/24953798
http://dx.doi.org/10.1038/srep05396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066261/
https://www.ncbi.nlm.nih.gov/pubmed/24953798
http://dx.doi.org/10.1038/srep05396

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