Structure-Function Correlation Analysis of Connexin50 Missense Mutations Causing Congenital Cataract: Electrostatic Potential Alteration Could Determine Intracellular Trafficking Fate of Mutants

Connexin50 (Cx50) mutations are reported to cause congenital cataract probably through the disruption of intercellular transport in the lens. Cx50 mutants that undergo mistrafficking have generally been associated with failure to form functional gap junction channels; however, sometimes even properl...

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Detalles Bibliográficos
Autores principales: Sarkar, Devroop, Ray, Kunal, Sengupta, Mainak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066682/
https://www.ncbi.nlm.nih.gov/pubmed/25003127
http://dx.doi.org/10.1155/2014/673895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066682/
https://www.ncbi.nlm.nih.gov/pubmed/25003127
http://dx.doi.org/10.1155/2014/673895

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