Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300

The E-protein transcription factors play essential roles in lymphopoiesis, with E12 and E47 (hereafter called E2A) being particularly important in B cell specification and maturation. The E2A gene is also involved in a chromosomal translocation that results in the leukemogenic oncoprotein E2A-PBX1....

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Detalles Bibliográficos
Autores principales: Denis, Christopher M., Langelaan, David N., Kirlin, Alyssa C., Chitayat, Seth, Munro, Kim, Spencer, Holly L., LeBrun, David P., Smith, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066744/
https://www.ncbi.nlm.nih.gov/pubmed/24682819
http://dx.doi.org/10.1093/nar/gku206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066744/
https://www.ncbi.nlm.nih.gov/pubmed/24682819
http://dx.doi.org/10.1093/nar/gku206

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