The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm

Robustness and completion of DNA replication rely on redundant DNA replication origins. Reduced efficiency of origin licensing is proposed to contribute to chromosome instability in CDK-deregulated cell cycles, a frequent alteration in oncogenesis. However, the mechanism by which this instability oc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayuda-Durán, Pilar, Devesa, Fernando, Gomes, Fábia, Sequeira-Mendes, Joana, Ávila-Zarza, Carmelo, Gómez, María, Calzada, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066753/
https://www.ncbi.nlm.nih.gov/pubmed/24753426
http://dx.doi.org/10.1093/nar/gku313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066753/
https://www.ncbi.nlm.nih.gov/pubmed/24753426
http://dx.doi.org/10.1093/nar/gku313

Ejemplares similares