DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1

Myotonic dystrophy type 1 (DM1) is caused by CUG triplet expansions in the 3′ UTR of dystrophia myotonica protein kinase (DMPK) messenger ribonucleic acid (mRNA). The etiology of this multi-systemic disease involves pre-mRNA splicing defects elicited by the ability of the CUG-expanded mRNA to ‘spong...

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Detalles Bibliográficos
Autores principales: Pettersson, Olof J., Aagaard, Lars, Andrejeva, Diana, Thomsen, Rune, Jensen, Thomas G., Damgaard, Christian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066779/
https://www.ncbi.nlm.nih.gov/pubmed/24792155
http://dx.doi.org/10.1093/nar/gku352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066779/
https://www.ncbi.nlm.nih.gov/pubmed/24792155
http://dx.doi.org/10.1093/nar/gku352

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