Positive and negative impacts of nonspecific sites during target location by a sequence-specific DNA-binding protein: origin of the optimal search at physiological ionic strength

The inducible transcription factor Egr-1, which recognizes a 9-bp target DNA sequence via three zinc-finger domains, rapidly activates particular genes upon cellular stimuli such as neuronal signals and vascular stresses. Here, using the stopped-flow fluorescence method, we measured the target searc...

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Detalles Bibliográficos
Autores principales: Esadze, Alexandre, Kemme, Catherine A., Kolomeisky, Anatoly B., Iwahara, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066804/
https://www.ncbi.nlm.nih.gov/pubmed/24838572
http://dx.doi.org/10.1093/nar/gku418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066804/
https://www.ncbi.nlm.nih.gov/pubmed/24838572
http://dx.doi.org/10.1093/nar/gku418

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