Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1

Mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1 and PMS2 are associated with Lynch Syndrome (LS), a familial predisposition to early-onset cancer of the colon and other organs. Because not all LS families carry mutations in these four genes, the search for cancer-associated mutations w...

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Detalles Bibliográficos
Autores principales: Bregenhorn, Stephanie, Jiricny, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066805/
https://www.ncbi.nlm.nih.gov/pubmed/24829445
http://dx.doi.org/10.1093/nar/gku419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066805/
https://www.ncbi.nlm.nih.gov/pubmed/24829445
http://dx.doi.org/10.1093/nar/gku419

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