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2,2,2-Trifluoroethyl 6-thio-β-d-glucopyranoside as a selective tag for cysteines in proteins

A synthetic route to a trifluoromethyl and thiol containing glucose derivative (2,2,2-trifluoroethyl 6-thio-β-d-glucopyranoside) is presented, which is based on microwave-assisted Fischer glycosylation under increased pressure. This water-soluble, neutral thiol-compound can be used to selectively in...

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Detalles Bibliográficos
Autores principales: Fröhlich, Richard F.G., Schrank, Evelyne, Zangger, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067056/
https://www.ncbi.nlm.nih.gov/pubmed/23000216
http://dx.doi.org/10.1016/j.carres.2012.08.010