Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response

BACKGROUND: Targeted therapy against the Epidermal Growth Factor Receptor (EGFR) is among the most promising molecular therapeutics for Head and Neck Squamous Cell Carcinoma (HNSCC). However, drug resistance limits the clinical efficacy of anti-EGFR monoclonal antibodies and no predictive biomarker...

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Detalles Bibliográficos
Autores principales: Boeckx, Carolien, Weyn, Christine, Vanden Bempt, Isabelle, Deschoolmeester, Vanessa, Wouters, An, Specenier, Pol, Van Laer, Carl, Van den Weyngaert, Danielle, Kockx, Mark, Vermorken, Jan B, Peeters, Marc, Pauwels, Patrick, Lardon, Filip, Baay, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067106/
https://www.ncbi.nlm.nih.gov/pubmed/24899223
http://dx.doi.org/10.1186/1756-0500-7-337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067106/
https://www.ncbi.nlm.nih.gov/pubmed/24899223
http://dx.doi.org/10.1186/1756-0500-7-337

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