Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation

The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a ubiquitin-independent manner both in vitro a...

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Detalles Bibliográficos
Autores principales: Belogurov, Alexey, Kudriaeva, Anna, Kuzina, Ekaterina, Smirnov, Ivan, Bobik, Tatyana, Ponomarenko, Natalia, Kravtsova-Ivantsiv, Yelena, Ciechanover, Aaron, Gabibov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067209/
https://www.ncbi.nlm.nih.gov/pubmed/24739384
http://dx.doi.org/10.1074/jbc.M113.544247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067209/
https://www.ncbi.nlm.nih.gov/pubmed/24739384
http://dx.doi.org/10.1074/jbc.M113.544247

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