Cargando…

Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension

Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH). To determine whether the TGF-β/ALK1/ENG pathway was involved in PAH, we investigated pulmonary TGF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gore, Benoît, Izikki, Mohamed, Mercier, Olaf, Dewachter, Laurence, Fadel, Elie, Humbert, Marc, Dartevelle, Philippe, Simonneau, Gerald, Naeije, Robert, Lebrin, Franck, Eddahibi, Saadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067299/ https://www.ncbi.nlm.nih.gov/pubmed/24956016 http://dx.doi.org/10.1371/journal.pone.0100310

Ejemplares similares

The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats
por: Izikki, Mohamed, et al.
Publicado: (2013)

Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
por: Sage, Edouard, et al.
Publicado: (2008)

ALK1 regulates the internalization of endoglin and the type III TGF-β receptor
por: Tazat, Keren, et al.
Publicado: (2021)

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
por: Huang, Qian, et al.
Publicado: (2022)

Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous
por: Perros, Frédéric, et al.
Publicado: (2019)

Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage
por: Garzon-Martinez, Mercedes, et al.
Publicado: (2020)

Endoglin and TGF-β signaling in glioblastoma
por: Burghardt, Isabel, et al.
Publicado: (2021)

Factors predicting outcome after pulmonary endarterectomy
por: Tromeur, Cécile, et al.
Publicado: (2018)

The Role of the TGF-β Coreceptor Endoglin in Cancer
por: Pérez-Gómez, Eduardo, et al.
Publicado: (2010)

Shear induced collateral artery growth modulated by endoglin but not by ALK1
por: Seghers, Leonard, et al.
Publicado: (2012)

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension
por: Hautefort, Aurélie, et al.
Publicado: (2017)

Endoglin modulates cellular responses to TGF-beta 1
Publicado: (1996)

Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats
por: Jacquin, S., et al.
Publicado: (2015)

Heme Oxygenase-1 and Inflammation in Experimental Right Ventricular Failure on Prolonged Overcirculation-Induced Pulmonary Hypertension
por: Belhaj, Asmae, et al.
Publicado: (2013)

Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling
por: Kumar, S, et al.
Publicado: (2014)

Regulation of TGF-β receptor hetero-oligomerization and signaling by endoglin
por: Pomeraniec, Leslie, et al.
Publicado: (2015)

Acute decompensated pulmonary hypertension
por: Savale, Laurent, et al.
Publicado: (2017)

Thresholds of Endoglin Expression in Endothelial Cells Explains Vascular Etiology in Hereditary Hemorrhagic Telangiectasia Type 1
por: Galaris, Georgios, et al.
Publicado: (2021)

Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling
por: Eleftheriou, Nikolas M., et al.
Publicado: (2016)

CFTR dysfunction increases endoglin and TGF‐β signaling in airway epithelia
por: Nicola, Teodora, et al.
Publicado: (2019)

Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
por: Dorfmüller, Peter, et al.
Publicado: (2011)

ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis
por: Liu, Zhen, et al.
Publicado: (2014)

Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis
por: Eddahibi, Saadia, et al.
Publicado: (2002)

French experience of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
por: Brenot, Philippe, et al.
Publicado: (2019)

Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils
por: Sahraoui, Abdelhamid, et al.
Publicado: (2016)

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin
por: Olsen, O E, et al.
Publicado: (2014)

Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
por: Mendez, Paul-Lennard, et al.
Publicado: (2022)

Toxicarioside A Inhibits Tumor Growth and Angiogenesis: Involvement of TGF-β/Endoglin Signaling
por: Huang, Feng-ying, et al.
Publicado: (2012)

Hybrid treatment of an aortic pseudoaneurysm arising at the innominate artery junction secondary to superior vena cava stenting
por: Roussel, Arnaud, et al.
Publicado: (2015)

Endoglin and Activin Receptor-like Kinase 1 (Alk1) Modify Adrenomedullin Expression in an Organ-Specific Manner in Mice
por: García-Sanmartín, Josune, et al.
Publicado: (2022)

High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils
por: Sahraoui, Abdelhamid, et al.
Publicado: (2020)

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
por: Rivera, Lee B., et al.
Publicado: (2011)

Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-β
por: Rossi, Elisa, et al.
Publicado: (2019)

Endoglin: Beyond the Endothelium
por: Schoonderwoerd, Mark J. A., et al.
Publicado: (2020)

MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin
por: Kaitu’u-Lino, Tu’uhevaha J., et al.
Publicado: (2012)

Mechanical versus humoral determinants of brain death-induced lung injury
por: Belhaj, Asmae, et al.
Publicado: (2017)

Description, Staging and Quantification of Pulmonary Artery Angiophagy in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
por: Perros, Frédéric, et al.
Publicado: (2020)

The Role of Endoglin in Hepatocellular Carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2021)

Endoglin in the Spotlight to Treat Cancer
por: González Muñoz, Teresa, et al.
Publicado: (2021)

Endoglin in head and neck neoplasms
por: Litwiniuk-Kosmala, Małgorzata, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9hhgtlbt7tpum2h329jp790cdp