From Pan-Reactive K(V)7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group

The voltage-gated potassium channels of the K(V)7 family (K(V)7.1–5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing K(V)7 channel active drugs has been...

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Detalles Bibliográficos
Autores principales: Blom, Sigrid Marie, Rottländer, Mario, Kehler, Jan, Bundgaard, Christoffer, Schmitt, Nicole, Jensen, Henrik Sindal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067310/
https://www.ncbi.nlm.nih.gov/pubmed/24956197
http://dx.doi.org/10.1371/journal.pone.0100209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067310/
https://www.ncbi.nlm.nih.gov/pubmed/24956197
http://dx.doi.org/10.1371/journal.pone.0100209

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