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From Pan-Reactive K(V)7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group
The voltage-gated potassium channels of the K(V)7 family (K(V)7.1–5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing K(V)7 channel active drugs has been...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067310/ https://www.ncbi.nlm.nih.gov/pubmed/24956197 http://dx.doi.org/10.1371/journal.pone.0100209 |