The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

Chemotherapy-induced peripheral neuropathy (CIPN) characterized by loss of sensory sensitivity and pain in hands and feet is the major dose-limiting toxicity of many chemotherapeutics. At present, there are no FDA-approved treatments for CIPN. The anti-diabetic drug metformin is the most widely used...

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Detalles Bibliográficos
Autores principales: Mao-Ying, Qi-Liang, Kavelaars, Annemieke, Krukowski, Karen, Huo, Xiao-Jiao, Zhou, Wenjun, Price, Theodore J., Cleeland, Charles, Heijnen, Cobi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067328/
https://www.ncbi.nlm.nih.gov/pubmed/24955774
http://dx.doi.org/10.1371/journal.pone.0100701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067328/
https://www.ncbi.nlm.nih.gov/pubmed/24955774
http://dx.doi.org/10.1371/journal.pone.0100701

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