Beclin 1 and UVRAG Confer Protection from Radiation-Induced DNA Damage and Maintain Centrosome Stability in Colorectal Cancer Cells

Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG) to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1 or UVRAG can regulate the DNA damage/repair r...

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Detalles Bibliográficos
Autores principales: Myung Park, Jae, Tougeron, David, Huang, Shengbing, Okamoto, Koichi, Sinicrope, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067383/
https://www.ncbi.nlm.nih.gov/pubmed/24956373
http://dx.doi.org/10.1371/journal.pone.0100819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067383/
https://www.ncbi.nlm.nih.gov/pubmed/24956373
http://dx.doi.org/10.1371/journal.pone.0100819

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